Modeling the human brain in order to study its physiology, development and diseases has been very challenging due to its structural and functional complexity and fragility. Brain organoids, derived from human pluripotent stem cells, opened a new approach to create in vitro 3D models, that more closely resemble the complexity of the brain, as compared to 2D cell cultures. So far, multiple developmental and neurodegenerative diseases have been generated with organoid technology and used as drug screening platforms not only to accelerate the development of more efficient treatments but also to get one step closer to personalized medicine. This review aims to showcase the current applications of brain organoids and review future perspectives and limitations.