In this review we explore the clinical importance of human Very Small Embryonic Like (hVSEL) stem cells as a source of pluripotent stem cells for use in regenerative medicine procedures. Autologous pluripotent hVSEL stem cells are a valuable resource in regenerative medicine especially when activated with Strachan-Ovokiatys Node Generator (SONG) modulated laser light. The review provides an overview of hVSEL stem cell technology and some insights into the massive potential of SONG modulated laser activated hVSEL stem cells regenerative medicine.