This opinion paper examines the current status of cord blood stem cell technology using volume reduction and describes a novel cord blood collection, processing and storage system. This technology could represent a new paradigm in using cord blood in regenerative medicine in the future. The decline in the use of cord blood to treat blood disorders, largely driven by haploidentical transplantation, may in the future be replaced by using cord blood in regenerative medicine procedures. The Evo3medica Sterile Closed Cryo-System (ESCCS) provides a closed cord blood collection, processing and storage system which will considerably reduce the cost of cord blood collection, processing and storage. The ESCCS enables easy collection, processing and storage of whole cord blood, with all of its constituent cells available for future regenerative medicine procedures. This will enable current cord blood banks to easily and cost-effectively switch their focus to regenerative medicine procedures. This is instead of focusing on the ever-decreasing use of cord blood in haemopoietic stem cell transplantation for blood disorders.